Reengineering Ribosome Export
نویسندگان
چکیده
منابع مشابه
Reengineering the Industrial CMMI
Abstract of Re-engineering of Industrial CMMI Through this research, I have established a general strategy to appraise an organization against a scale of five process maturity levels whilst maintaining a strong mechanics of CMMI. Reengineering of industrial CMMI proposes a novel method for Industrial Competence ranking of those organizations/companies which are targeting various CMM...
متن کاملSynthesis through Nucleophosmin Translation TSC1 Sets the Rate of Ribosome Export and Protein
Nucleophosmin (B23) is a nucleolar phosphoprotein that has been implicated in numerous cellular processes. In particular, nucleophosmin interacts with nucleolar components of newly synthesized ribosomes to promote ribosome nuclear export. Nucleophosmin is a classic mitogen-induced protein, with changes in its expression correlating with growth factor stimulation. In this study, we examined the ...
متن کاملCoupled GTPase and remodelling ATPase activities form a checkpoint for ribosome export
Eukaryotic ribosomes are assembled by a complex pathway that extends from the nucleolus to the cytoplasm and is powered by many energy-consuming enzymes 1-3. Nuclear export is a key, irreversible step in pre-ribosome maturation4-8, but mechanisms underlying the timely acquisition of export competence remain poorly understood. Here we show that a conserved GTPase Nug2/ Nog2 (called NGP-1, Gnl2 o...
متن کاملA pre-ribosome-associated HEAT-repeat protein is required for export of both ribosomal subunits.
Rrp12p (Ypl012w) is unusual among characterized ribosome synthesis factors in being associated with late precursors to both the 40S and 60S subunits. Rrp12p is predominantly nuclear with nucleolar enrichment at steady state, but shuttled between the nucleus and cytoplasm in a heterokaryon assay. Strains depleted of Rrp12p are impaired in the nuclear export of both ribosomal subunits. Sequence a...
متن کاملNucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome.
Nucleophosmin (NPM) (B23) is an essential protein in mouse development and cell growth; however, it has been assigned numerous roles in very diverse cellular processes. Here, we present a unified mechanism for NPM's role in cell growth; NPM directs the nuclear export of both 40S and 60S ribosomal subunits. NPM interacts with rRNA and large and small ribosomal subunit proteins and also colocaliz...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2009
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e08-10-1000